395013).Īt first, patients diagnosed with Type 2 DM who were treated by metformin tablet alone or in combination with other oral antidiabetic drugs were invited to participate in the study. The study obtained approval from the Research Council and Ethics Committee of Isfahan University of Medical Sciences (No. This prospective interventional study was conducted from June to November 2016 at DM clinics affiliated to Isfahan University of Medical Sciences, Isfahan, Iran. In this study, we aimed to compare the patients’ satisfaction and GI side effects of oral metformin in either dosage forms of tablet or capsule. Although these GI side effects often diminish over time and can be minimized by careful dose adjustment and taking metformin at mealtimes, they may impair compliance and cause approximately 5% of patients to discontinue therapy. The most common GI side effects associated with metformin are diarrhea, nausea, and vomiting (with a prevalence of 2%–63% according to the recent literature) which occur more than all other oral antidiabetic agents. Gastrointestinal (GI) side effects are the main complaint of patients receiving metformin tablet. It also has very low risk for including lactic acidosis as a side effect. Metformin, a biguanide antihyperglycemic medication, is still considered as the best medication and the first line of treatment either as monotherapy or in combination with other drugs for Type 2 DM due to its efficacy, very low risk of hypoglycemia and weight gain, and low cost. High prevalence of this disorder imposes a significant burden to the global health, and thus, numerous efforts have been utilized for both prevention and management of this worldwide concern. Type 2 diabetes mellitus (DM) is a chronic and progressive disease, which needs strict monitoring and control from diagnosis and also through different stages of the disease.
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